Thirty patients over 60 years of age suffering from muscle hypotrophy of the lower limbs due to fracture of the thigh were submitted to rehabilitation training, physiokinesi-therapy with and without administration of creatine phosphate (500 mg daily i.m. for 20 days). In order to access the efficacy of therapy, manual measurement of the circumference of thigh and leg and echotomography were performed in order to measure the thickness of the muscle layer. Manual measurement did not prove to be a reliable method for evaluation due to the frequent presence of edematous swelling. After 20 days of physiokinesitherapy, echotomography revealed marked recovery of the muscle mass in the 15 patients treated with creatine phosphate who had an increase in muscle mass of 4.4 mm against only 1.5 mm in the group treated with physiokinesitherapy only. This difference is statistically significant (p < 0.01).