It has recently been demonstrated that oral creatine (Cr) supplementation can increase muscle phosphocreatine (PCr) and Cr availability (Harris et al. 1992) and delay the development of fatigue during repeated bouts of maximal exercise in man (Greenhaff et al. 1992). The aim of the present experiment was to investigate the effect of oral Cr supplementation on muscle PCr resynthesis following intense contraction in man. 12 healthy subjects (2 females, 10 males) underwent twenty intense percutaneous electrically evoked (50 Hz) isometric contractions of the quadriceps (n=6) or anterior tibialis (n=6) muscle groups, with limb blood flow occluded, before and after oral Cr ingestion (20 g per day for 5 days). Each contraction lasted for 1.6 s and was separated by 1.6 s rest. At the end of recovery following Cr supplementation, PCr was 20% higher in biopsy samples (P<0.05) and 11% higher in MRS scans. In both experiments, 5 from each group demonstrated an accelerated rate of PCr resynthesis after Cr ingestion. Our preliminary findings suggest that oral Cr supplementation may accelerate the rate of muscle PCr resynthesis following intense contraction.